Selected Publications

  1. Bishara LA, Machour FE, Awwad SW, Ayoub N. NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition. DNA Repair (Amst), November 2020. PubMed
  2. Machour F.E, Ayoub N. Transcriptional Regulation at DSBs: Mechanisms and Consequences.Trends Genet, January 2020. PubMed
  3. Abu-Zhayia, E.R, Machour, F.E, Ayoub N. HDAC-dependent decrease in histone crotonylation during DNA damage. J Mol Cell Biol, September 2019. PubMed
  4. Abu-Zhayia, E.R., Awwad, S.W., Ben-Oz, B.M., Khoury-Haddad, H., Ayoub, N.  CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair. J Mol Cell Biol, August 2018. PubMed
  5. Jbara M, Guttmann-Raviv N. Maity SK. Ayoub N* and Brik A*. Total Chemical Synthesis of Methylated Analogues of Histone 3 Revealed KDM4D as a Potential Regulator of H3K79me3. Bioorganic and Medicinal Chemistry, April, 2017. * Equal corresponding authors. PubMed
  6. Abu-Zhaiya ER, Khoury-Haddad H, Guttmann-Raviv N. Serruya, J. Jarrous, Ayoub N. A role for human RNase P subunits in homology directed-repair of double-strand breaks. Scientific Reports 2017;7:1002. PubMed
  7. Awwad SW, Abu-Zhaiya ER, Guttmann-Raviv, Ayoub N. NELF-E is recruited to DNA double-strand break sites to promote transcription repression and repair. EMBO Rep. 2017;18:745-64. PubMed
  8. News & Views. Polo SE. Switching genes to silent mode near DNA double-strand breaks. EMBO Rep. 2017;18:659-60. PubMed
  9. Khoury-Haddad H, Nadar-Ponniah PT, Awwad S, Ayoub N. The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites. Cell Cycle 14, 950-958 (2015). PubMed
  10. News & Views. Goldberg M. KDM4D crosstalks with PARP1 and RNA at DNA DSBs. Cell Cycle. 2015; 14:1495. PubMed
  11. Awwad SW, Ayoub N. Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway. Biology open 4, 498-504 (2015). PubMed
  12. Zoabi, M., Nadar-Ponniah, P. T., Khoury-Haddad, H., Usaj, M., Budowski-Tal, I., Haran, T., Henn, A., Mandel-Gutfreund, Y. and Ayoub, N. RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation. Nucleic Acids Res 42, 13026-13038 (2014). PubMed
  13. Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci U S A (PLUS) 111, E728-737 (2014). PubMed
    Awarded the Jacob’s prize for the excellent published paper.
  14. Kupershmit I, Khoury-Haddad H, Awwad SW, Guttmann-Raviv N, Ayoub N. KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res 42, 6168-6182 (2014). PubMed
  15. Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem 288, 14681-14687 (2013). PubMed