Publications

2021-2024

Machour, F. E., Abu-Zhayia, E., Kamar, J., Barisaac, A. S., Simon, I., and Ayoub, N. (2023). Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma. bioRxiv, 2023. Link

Ben-Oz, B. M., Machour, F. E., Nicola, M., Argoetti, A., Polyak, G., Hanna, R., Kleifeld, O., Mandel-Gutfreund, Y., and Ayoub, N. (2023) A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response. Nature communications 14, 7628. PubMed

Awwad, S. W., Darawshe, M. M., Machour, F. E., Arman, I., and Ayoub, N. (2023) Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair. Mol Cell Biol 43, 130-142. PubMed

-Vamisetti, G. B., Saha, A., Huang, Y. J., Vanjari, R., Mann, G., Gutbrod, J., Ayoub, N., Suga, H., and Brik, A. (2022) Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair. Nature communications 13, 6174. PubMed

Abu-Zhayia, E.R., Bishara, L.A., Machour, F.E., Barisaac, A.S., Ben-Oz, B.M., and Ayoub, N. (2022) CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair. Mol Cell. 82, 1940-1955 e1947.PubMed

Machour, F.E., Abu-Zhayia, E.R., Awwad, S.W., Bidany-Mizrahi, T., Meinke, S., Bishara, L.A., Heyd, F., Aqeilan, R.I., and Ayoub, N. (2021) RBM6 splicing factor promotes homologous recombination repair of double-strand breaks and modulates sensitivity to chemotherapeutic drugs. Nucleic Acids Res. 49, 11708-11727. PubMed

Bishara LA, Machour FE, Awwad SW, Ayoub N. (2021) NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition. DNA Repair Amst, 97, 103025. PubMed

2017-2020

Machour F.E, Ayoub N. (2020) Transcriptional Regulation at DSBs: Mechanisms and Consequences. Trends Genet, 36, 981-997. PubMed

Nebenzahl-Sharon, K., Shalata, H., Sharf, R., Amer, J., Khoury-Haddad, H., Sohn, S.Y., Ayoub, N., Hearing, P., and Kleinberger, T. (2019) Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK. J Virol. 93(10): e01365-18. PubMed

Nebenzahl-Sharon, K., Sharf, R., Amer, J., Shalata, H., Khoury-Haddad, H., Sohn, S.Y., Ayoub, N., Hearing, P., and Kleinberger, T. (2019) An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein. J Virol. 93(19):e02253-18. PubMed

Abu-Zhayia, E.R, Machour, F.E, Ayoub N. (2019). HDAC-dependent decrease in histone crotonylation during D NA damage. J Mol Cell Biol, 11, 804-806. PubMed

Abu-Zhayia, E.R., Awwad, S.W., Ben-Oz, B.M., Khoury-Haddad, H., Ayoub, N. (2018) CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair. J Mol Cell Biol, 10, 341-357. PubMed

Jbara M, Guttmann-Raviv N. Maity SK. Ayoub N* and Brik A*. (2017) Total Chemical Synthesis of Methylated Analogues of Histone 3 Revealed KDM4D as a Potential Regulator of H3K79me3. Bioorg Med Chem, * Equal corresponding authors.25(18):4966-4970.  PubMed

Abu-Zhaiya ER, Khoury-Haddad H, Guttmann-Raviv N. Serruya, J. Jarrous, Ayoub N. (2017) A role for human RNase P subunits in homology directed-repair of double-strand breaks. Scientific Reports. 7:1002. PubMed

Awwad SW, Abu-Zhaiya ER, Guttmann-Raviv, Ayoub N. (2017) NELF-E is recruited to DNA double-strand break sites to promote transcription repression and repair. EMBO Rep. 18:745-64. PubMed

–News & Views. Polo SE. (2017) Switching genes to silent mode near DNA double-strand breaks. EMBO Rep. 18:659-60. PubMed

2013-2016

Khoury-Haddad H, Nadar-Ponniah PT, Awwad S, Ayoub N. (2015) The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites. Cell Cycle 14, 950-958. PubMed

-News & Views. Goldberg M. (2015). KDM4D crosstalks with PARP1 and RNA at DNA DSBs. Cell Cycle 14:1495. PubMed

Awwad SW, Ayoub N. (2015). Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway. Biology open 4, 498-504. PubMed

Zoabi, M., Nadar-Ponniah, P. T., Khoury-Haddad, H., Usaj, M., Budowski-Tal, I., Haran, T., Henn, A., Mandel-Gutfreund, Y. and Ayoub, N. (2014) RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation. Nucleic Acids Res 42, 13026-13038. PubMed

Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc Natl Acad Sci USA Plus 111, E728-737. PubMed
Awarded the Jacob’s prize for the excellent published paper.

Kupershmit I, Khoury-Haddad H, Awwad SW, Guttmann-Raviv N, Ayoub N. (2014) KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res 42, 6168-6182. PubMed

Jeyasekharan, A.D., Liu, Y., Hattori, H., Pisupati, V., Jonsdottir, A.B., Rajendra, E., Lee, M., Sundaramoorthy, E., Schlachter, S., Kaminski, C.F., Ayoub, N. (2013), and Venkitaraman, A.R. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol 20, 1191-1198. PubMed.

Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N. (2013) Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J Biol Chem 288, 14681-14687. PubMed