Each cell in our body could experience tens of thousands of DNA lesions per day. Fortunately, cells have evolved a sophisticated network of cellular mechanisms, termed the DNA damage response (DDR), to detect DNA lesions and facilitate their repair. Defective DDR could lead to accumulation of mutations and genomic instabilities that contribute to premature aging, developmental disorders, neurodegenerative disease and cancer.
Our lab is interested in understanding how the cells repair the broken DNA. We focus on identifying new DDR proteins, characterizing their role in DNA damage repair and cancer development. Our ultimate goal is to translate our findings into diagnostic and therapeutic tools to defeat cancer and other related diseases.
DNA damage response, CRISPR-Cas9 genome editing, Targeted cancer therapy, Genomic instability, Carcinogenesis, Chromatin post-translational modifications.